You can merge pdfs or a mix of pdf documents and other files. Skin nonmelanocytic tumors lymphoepitheliomalike carcinoma. A form of cancer, carcinoma makes up the majority of the cases of malignancy of the breast, uterus, intestinal tract, skin, and tongue. The ulcerations represent punch biopsies figure 2 an invasive carcinoma originates from the epidermis and pen. Thyroid benign lymphoepithelial lesions are rare in adults, reported as associated with thyroiditis or adjacent to tumours.
Undifferentiated carcinoma of the oropharynx nature. Click, drag, and drop to reorder files or press delete to remove any content you dont want. Lymphoepithelial carcinoma of the minor salivary gland. On the surgical resection specimen, in addition to a 2cm follicular. Primary lymphoepitheliallike carcinoma of the parotid. Primary lymphoepitheliomalike carcinoma of the prostate. Paraneoplastic cerebellar degeneration associated with lymphoepithelial carcinoma of the tonsil christian henke 1, johannes rieger 2, sylvia hartmann 3, marcus middendorp 4, helmuth steinmetz 1. The treatment for lymphoepithelial carcinoma of salivary gland involves a combination of surgery, chemotherapy, and radiation therapy, in most cases. Lymphoepithelial like carcinomas of the head and neck are histologically similar to nasopharyngeal carcinoma nonkeratinizing undifferentiated type but by definition arise in mucosal sites other than the nasopharynx. Lymphoepithelial carcinoma lec consists of poorly differentiated squamous cell carcinoma or histologically undifferentiated carcinoma accompanied by prominent reactive lymphoplasmacytic infiltration. Benign lymphoepithelial lesion blel is a morphologic term introduced bygodwin1 in 1952 to des ignatea varietyofclinicaland patho logic disorders affectingsalivarytis sue. Lymphoepitheliomalike carcinoma of the skin can j plast surg vol 10 no 5 novemberdecember 2002 221 figure 1 lymphoepitheliomalike carcinoma of the skin on the upper arm of a 38yearold woman just before excisional biopsy. Lymphoepitheliomalike carcinoma of the breast is a rare tumor, with fewer than 20 cases documented in the literature.
The presented study summaries the literature controversies in the treatment of lec and present a case of a rare lec diagnosed in the sublingual gland of an otherwise healthy 21yearold arab woman. Lymphoepitheliomalike gastric carcinoma is a rare type of gastric cancer characterized by a carcinoma with intense stromal lymphocytic infiltration. Previous reports have described a higher prevalence of this clinicopathological entity in southern chinese, japanese and eskimo population. Hpv testing has disclosed a previously unrecognized morphologic variant of hpvhnscc that is microscopically indistinguishable from ebvrelated carcinoma. Pdf lymphoepithelial carcinoma of the larynx kouadir. Investigations revealed a muscleinvasive lymphoepitheliomalike carcinoma of. Most cases of lec occur in the nasopharynx and are pathologically classified as a nonkeratinizing undifferentiated type of nasopharyngeal.
Lymphoepithelial carcinoma of parotid gland a case report article pdf available in journal of krishna institute of medical sciences university 32. However, it can also occur in other organs including the salivary glands, particularly the parotid and submandibular glands. We report the case of a 64yearold moroccan man who presented with macroscopic hematuria. To the best of our knowledge this is the first case of an association of a lymphoepithelial carcinoma, a rare pharyngeal tumor, with pcd. Who gets lymphoepithelial carcinoma of salivary gland. However, no risk factor is known for lelc of the bladder 4.
Rearrange individual pages or entire files in the desired order. Epsteinbarr virusassociated with lymphoepithelial carcinoma. Pdf lymphoepithelial carcinoma of the salivary glands. In this study, the authors evaluated 21 patients with. The purpose of this study was to evaluate the treatment results and failure patterns of lymphoepitheliomalike carcinoma lelc of salivary glands. Pdf lymphoepithelial carcinoma of parotid gland a case. Histopathologic slides revealed lymphoepithelial carcinoma lec that stained positive for cytokeratin, as well as epsteinbarr virus ebv. Case report epsteinbarr virus associated lymphoepithelial. Primary lymphoepithelial carcinoma plec is a rare subtype of salivary gland cancers, which comprises only 0. Lymphoepithelial carcinoma, which is a variant of undifferentiated carcinoma, is distinguished from small cell and large cell undifferentiated carcinoma by its association with benign lymphoepithelial lesions. It has a high tendency to metastasize and is responsive to radiotherapy. Lymphoepithelioma is a type of poorly differentiated nasopharyngeal carcinoma characterized by prominent infiltration of lymphocytes in the area involved by tumor. S y leung, l p chung, s t yuen, c m ho, m p wong, and s y chan department of pathology, university of hong kong, queen mary hospital compound, hong kong. Lymphoepithelial carcinoma lec of the parotid gland is a rare malignant tumor of salivary gland.
In major salivary glands, mucoepidermoid carcinoma, adenoid cystic carcinoma, acinic cell carcinoma, all types of adenocarcinoma, and carcinoma ex. Lymphoepithelioma is also known as class iii nasopharyngeal carcinoma in the who classification system. Lymphoepithelial carcinoma of the salivary glands ncbi. Lymphoepithelial carcinoma lec, also called lymphoepitheliomalike carcinoma, is defined as an undifferentiated carcinoma or poorly differentiated squamous cell carcinoma, accompanied by a prominent reactive lymphoplasmacytic infiltrate. Lymphoepitheliomalike carcinoma vs inflamed squamous cell. Patient files were examined and histopathologic slides were. Histological examination after tonsillectomy demonstrated a lymphoepithelial carcinoma of the tonsil and the tongue base strongly suggesting a paraneoplastic cause of the cerebellar syndrome. Lymphoepitheliomalike carcinomas lelc have a distinctive syncytial growth pattern with associated nonneoplastic lymphoid stroma. Pathology outlines lymphoepitheliomalike carcinoma. Rationale lymphoepithelial carcinoma lec is a rare malignancy with the histopathological feature of undifferentiated carcinoma and an intermixed reactive lymphoplasmacytic infiltration. Case report a case of predominant lymphoepitheliomalike.
The prognosis of the individual depends upon a set of several factors including the tumor stage and overall health of the individual. Herein, we report two cases of lec in the head and neck region that presented to oulu university hospital. Primary lymphoepithelial carcinoma plec is a very unusual subtype of salivary gland cancers, which involves mainly the parotid gland1,2. Lec can occur in many organs, but is most common in head and neck regions including pharynx. Plelcp is extremely rare and there are hardly any pictures of the tumour involving the prostate. This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment. Lymphoepithelial carcinoma of the larynx is a rare tumor, as this histological entity is mostly diagnosed in nasopharynx. Lymphoepithelial carcinoma of the larynx accounts only for 0.
The patient received a total left parotidectomy and a selective neck dissection. The relationship between epsteinbarr virus ebv and laryngeal lymphoepithelial. An lec of the parotid is a rare salivary gland tumor accounting for less than 1% of all salivary gland tumors. Although clinically significant because of its malignant nature, it is difficult to make a differential diagnosis by preoperative imaging. Case report primary lymphoepithelial carcinoma of the parotid. How to merge pdfs and combine pdf files adobe acrobat dc. Lymphoepithelial carcinoma of the salivary glands is a rare neoplasm that is characterized by a nonneoplastic lymphocytic infiltration associated with an epithelial proliferation. Lymphoepithelial carcinoma lec is a rare malignancy with the histopathological feature of undifferentiated carcinoma and an intermixed. Pdf background lymphoepithelial carcinoma is a tumor mostly diagnosed in the nasopharynx, but it has also been described in a variety of. Furthermore for the salivary plec have been used different terms as. We report a case of a lymphoepithelial carcinoma developing in a minor salivary gland of the oral cavity in a 69yearold woman.
For carcinomas of the head and neck that exhibit lymphoepithelial features, one cannot assume an ebvdriven process by morphology alone. A patient with plec of the parotid gland, its management and the available literature are presented. Lymphoepitheliomalike carcinoma of the prostate request pdf. Original article primary lymphoepitheliomalike carcinoma of. Lymphoepitheliomalike carcinoma lelc is a medical term referring to a histological variant of malignant tumor arising from the uncontrolled mitosis of transformed cells originating in epithelial tissue or in cells that display epithelial characteristics that bear microscopic resemblance to lymphoepithelioma nasopharyngeal carcinoma. Lymphoepithelial carcinoma lec is an uncommon malignant tumor composed of undifferentiated malignant epithelial cells with characteristic lymphoid stroma. The majority of lelc are epstein barr virus ebvassociated. Although lymphocytic infiltration is closely associated with epsteinbarr virus ebv infection, concomitant occurrence with differentiated adenocarcinoma is relatively rare. Our first case is a 30yearold man with lec in the left maxillary sinus. A 56yearold woman presented with a thyroid nodule increasing in size. Pathology outlines lymphoepitheliomalike thymic carcinoma. Lymphoepitheliallike carcinomas of the head and neck.
Histologically, it is an undifferentiated carcinoma with an intermixed reactive lymphoplasmacytic infiltrate. Lymphoepithelial carcinoma lec is a rare malignancy. Lymphoepithelial carcinoma malignant lymphoepithelial. Lymphoepitheliomalike carcinoma of the skin lelcs is a very rare primary skin neoplasm that most frequently occurs on the sunexposed skin of the head and neck in elderly individuals. Ebvassociated lymphoepithelial carcinoma of the salivary glands. Lymphoepitheliomalike carcinoma is a rare tumor of the bladder for which the therapeutic strategy is not clearly defined. Lymphoepithelial carcinoma lec is a rare malignancy with the histopathological feature of undifferentiated carcinoma and an intermixed reactive lymphoplasmacytic infiltration. Lymphoepithelial carcinoma affects children and adults and presents at a mean age of approximately 55 years. Well circumscribed lobules, nests or small aggregates of large, cohesive, epithelioid cells closely associated with a dense, mixed t and b lymphocytic and plasmacytic infiltrate rare tumors 20. These tumors are exceedingly rare and aggressive neoplasm. Here we report a unique case of a thyroid solid nodule with benign lymphoepithelial morphology.
The nomenclature for carcinomas of the nasopharynx has undergone several iterations, but a lymphoepithelial carcinoma of the sinonasal tract has recently been accepted as a distinct entity, separated from nasopharyngeal carcinoma by topography, but still similar histologically. Although clinically significant because of its malignant nature, it is difficult to make a. Lymphoepitheliomalike carcinoma lelc of salivary glands is a rare kind tumor. The classic histopathologiclesion is composed of acinar atrophy, lymphocytic sialadenitis, and ductal epi thelial hyperplasia and metaplasia. Click add files and select the files you want to include in your pdf. Ebvassociated lymphoepitheliomalike carcinoma of the. Controversies exist in the current literature regarding the treatment of lymphoepithelial carcinoma lec.
Lymphoepithelial carcinoma lec is a rare subtype of oral carcinoma. Most cases of lymphoepithelial carcinoma lec occur in the nasopharynx, and lec in the. We report a 37yearold man from northern china who presented with a parotid gland neoplasm. Primary lymphoepitheliomalike carcinoma of the prostate gland plelcp is rare with hardly any information on its diagnostic features and biological behaviour.
To our knowledge, three cases of ebvassociated carcinomas have been reported to originate in the pancreas. The lymphoepithelial carcinoma of the nasopharynx is strongly associated with infection with the epsteinbarr virus ebv. Case report primary lymphoepithelial carcinoma of the. A rare case of lymphoepithelial carcinoma of the lip. Paraneoplastic cerebellar degeneration associated with. Merge pdf files combine pdfs in the order you want with the easiest pdf merger available.
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